Low-E 452 with argon is a step up from Low-E 366 for blocking the Arizona sun. It lets 52% of visible light through (center-of-glass measurement). Its solar heat gain coefficient (SHGC) is 0.22. SHGC is the share of the sun’s heat that gets through the glass, so lower is better here in the Valley. Low-E 366 measured the same way is 0.27.
It also blocks 99% of UV light, compared with 95% for Low-E 366. UV is what fades floors, furniture and blinds. The U-factor, which measures how fast heat moves through the glass, is 0.24 for both. So the gain is in keeping the sun’s heat out, not in insulation.
The trade-off is daylight. At 52%, it lets in less light than Low-E 366 at 65%. On a west- or south-facing wall in Phoenix, less glare and less heat is usually a trade worth making.
All of these numbers are for the glass alone, at the center of the glass: dual-pane, 3 mm glass, a half-inch argon-filled gap, measured to the NFRC 100 standard. A whole window, frame included, will have different numbers. See
energy efficient windows for how the window as a whole is rated.